Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14860190 | 0.81 | DPP7 (0.52) | FOLH1GLASLC6A2SLC6A4MEP1A | |
| SCHEMBL18930742 | 0.81 | DPP7 (0.52) | FOLH1GLASLC6A2SLC6A4MEP1A | |
| SCHEMBL28046794 | 0.81 | GLA (0.55) | FOLH1GLASLC6A2SLC6A4MEP1A | |
| SCHEMBL22395447 | 0.81 | FOLH1 (0.50) | FOLH1GLASLC6A2SLC6A4MEP1A | |
| SCHEMBL10606037 | 0.81 | FOLH1 (0.50) | FOLH1GLASLC6A2SLC6A4MEP1A | |
| Hydrochloric Acid SCHEMBL21144734 | 0.80 | DPP7 (0.51) | FOLH1GLASLC6A2SLC6A4MEP1A | |
| Hydrochloric Acid SCHEMBL21144735 | 0.80 | DPP7 (0.51) | FOLH1GLASLC6A2SLC6A4MEP1A | |
| SCHEMBL29478750 | 0.77 | GLA (0.50) | FOLH1GLAMEP1AMEP1BCYP19A1 | |
| SCHEMBL92972 | 0.77 | GLA (0.50) | FOLH1GLAMEP1AMEP1BCYP19A1 | |
| SCHEMBL407703 | 0.77 | SLC6A2 (0.45) | FOLH1GLASLC6A2SLC6A4MEP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9056859-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2015-06-16 | — | — | US | disclosed |
| EP-2632464-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2015-04-29 | — | — | EP | disclosed |
| EP-2632464-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| US-20130217680-A1 | Inhibitors of the Renal Outer Medullary Potassium Channel | MERCK SHARP & DOHME LLC | 2013-08-22 | — | — | US | disclosed |
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |
| EP-0201823-B1 | NOVEL INTERMEDIATES FOR THE PRODUCTION OF PHARMACEUTICALS | LILLY INDUSTRIES LIMITED (GB) | 1990-12-05 | — | — | EP | disclosed |
| US-4963578-A | LEUKOTRIN ANTAGONISTS; ANTIALLERGENS | LILLY INDUSTRIES LIMITED (GB) | 1990-10-16 | — | — | US | disclosed |
| US-RE33300-E | LEUKOTRIENE ANTAGONISTS; ANTIALLERGENS | ELI LILLY AND COMPANY (US) | 1990-08-14 | — | — | US | disclosed |
| EP-0134111-B1 | ARALIPHATIC SULPHIDES,SULPHONES AND SULPHOXIDES AND THEIR PHARMACEUTICAL USE | Lilly Industries Limited (GB) | 1988-12-07 | — | — | EP | disclosed |
| US-4665189-A | LEUKOTRIENE ANTAGONISTS | LILLY INDUSTRIES LIMITED (GB) | 1987-05-12 | — | — | US | disclosed |
| EP-0201823-A2 | Novel intermediates for the production of pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1986-11-20 | — | — | EP | disclosed |
| EP-0134111-A1 | Araliphatic sulphides,sulphones and sulphoxides and their pharmaceutical use | Lilly Industries Limited (GB) | 1985-03-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217680-A1 | Inhibitors of the Renal Outer Medullary Potassium Channel | KCNJ11, KCNJ1, KCNJ2 | FOLH1 4636/4885GLA 4494/4885SLC6A2 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.