Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.74 |
| ▸ | PIK3CA | P42336 | 19/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713488 | 1.00 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2712228 | 0.97 | PIK3CD (0.78) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2714421 | 0.90 | PIK3CD (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2712981 | 0.90 | PIK3CD (0.79) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL13019001 | 0.89 | PIK3CD (0.68) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2711945 | 0.89 | PIK3CD (0.68) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2711508 | 0.89 | PIK3CD (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2712160 | 0.88 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2711703 | 0.88 | PIK3CD (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2712531 | 0.88 | PIK3CD (0.65) | PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445886-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151791-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |