Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 17/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15191976 | 1.00 | KCNJ1 (0.76) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL15191944 | 1.00 | KCNJ1 (0.76) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL15191974 | 1.00 | KCNJ1 (0.76) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL4549536 | 1.00 | KCNJ1 (0.76) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL15196933 | 0.91 | KCNJ1 (0.67) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL15196764 | 0.91 | KCNJ1 (0.67) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL4549557 | 0.89 | KCNJ1 (0.75) | KCNJ1KCNH2SLC6A4 | |
| SCHEMBL4549649 | 0.87 | KCNJ1 (0.64) | KCNJ1KCNH2 | |
| SCHEMBL4549650 | 0.87 | KCNJ1 (0.64) | KCNJ1KCNH2 | |
| SCHEMBL4549346 | 0.87 | KCNJ1 (1.00) | KCNJ1KCNH2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632464-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |