Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.52 |
| ▸ | JAK2 | O60674 | 6/20 | 0.52 |
| ▸ | JAK3 | P52333 | 6/20 | 0.52 |
| ▸ | JAK1 | P23458 | 5/20 | 0.52 |
| ▸ | SYK | P43405 | 4/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30923144 | 1.00 | TYK2 (0.52) | TYK2JAK2JAK3JAK1SYK | |
| SCHEMBL30923225 | 0.91 | JAK3 (0.51) | TYK2JAK2JAK3JAK1SYK | |
| SCHEMBL27290259 | 0.91 | JAK3 (0.51) | TYK2JAK2JAK3JAK1SYK | |
| SCHEMBL27292535 | 0.91 | CCNK (0.47) | TYK2JAK2JAK3JAK1MAPK8 | |
| SCHEMBL30923145 | 0.91 | CCNK (0.47) | TYK2JAK2JAK3JAK1MAPK8 | |
| SCHEMBL27290121 | 0.90 | TYK2 (0.57) | TYK2JAK2JAK3JAK1SYK | |
| SCHEMBL27289976 | 0.90 | SYK (0.47) | TYK2JAK2JAK3JAK1SYK | |
| SCHEMBL30923147 | 0.88 | JAK2 (0.48) | TYK2JAK2JAK3JAK1SYK | |
| SCHEMBL27290899 | 0.88 | JAK2 (0.48) | TYK2JAK2JAK3JAK1SYK | |
| SCHEMBL27290481 | 0.87 | JAK2 (0.47) | TYK2JAK2JAK3JAK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107658-A2 | INHIBITORS OF TYK2 | VYRNWY THERAPEUTICS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |