Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.44 |
| ▸ | JAK2 | O60674 | 5/20 | 0.44 |
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | TYK2 | P29597 | 4/20 | 0.44 |
| ▸ | STAT6 | P42226 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2696305 | 0.92 | JAK3 (0.54) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2696792 | 0.91 | JAK3 (0.49) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2729062 | 0.89 | JAK3 (0.43) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2696031 | 0.80 | JAK3 (0.68) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2695405 | 0.80 | JAK3 (0.71) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2694470 | 0.79 | JAK3 (0.54) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2695608 | 0.78 | JAK3 (0.51) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2696694 | 0.78 | JAK3 (0.58) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2479411 | 0.78 | JAK3 (0.54) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2694027 | 0.78 | JAK3 (0.53) | JAK3IRAK4JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |