Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.48 |
| ▸ | TYK2 | P29597 | 8/20 | 0.46 |
| ▸ | JAK1 | P23458 | 7/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27414932 | 0.88 | TYK2 (0.49) | SYKTYK2JAK1KCNH2JAK3 | |
| SCHEMBL31711632 | 0.88 | TYK2 (0.49) | SYKTYK2JAK1KCNH2JAK3 | |
| SCHEMBL30923289 | 0.88 | JAK1 (0.45) | SYKTYK2JAK1KCNH2JAK3 | |
| SCHEMBL27291299 | 0.88 | JAK1 (0.45) | SYKTYK2JAK1KCNH2JAK3 | |
| SCHEMBL27298190 | 0.87 | JAK1 (0.44) | SYKTYK2JAK1KCNH2JAK3 | |
| SCHEMBL27291200 | 0.86 | SYK (0.47) | SYKTYK2JAK1JAK3JAK2 | |
| SCHEMBL30923162 | 0.86 | SYK (0.47) | SYKTYK2JAK1JAK3JAK2 | |
| SCHEMBL27415083 | 0.83 | JAK1 (0.46) | SYKTYK2JAK1KCNH2JAK3 | |
| SCHEMBL31711637 | 0.83 | JAK1 (0.46) | SYKTYK2JAK1KCNH2JAK3 | |
| SCHEMBL31711662 | 0.83 | TYK2 (0.48) | SYKTYK2JAK1KCNH2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107658-A2 | INHIBITORS OF TYK2 | VYRNWY THERAPEUTICS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |