Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 19/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729298 | 1.00 | SYK (0.66) | SYKABL1PDGFRBBCRSRC | |
| SCHEMBL2731132 | 0.92 | SYK (0.55) | SYKABL1PDGFRBBCRSRC | |
| SCHEMBL2731135 | 0.92 | SYK (0.55) | SYKABL1PDGFRBBCRSRC | |
| SCHEMBL2728948 | 0.91 | SYK (0.53) | SYK | |
| SCHEMBL2728953 | 0.91 | SYK (0.53) | SYK | |
| SCHEMBL2716063 | 0.87 | SYK (0.64) | SYK | |
| SCHEMBL2716067 | 0.87 | SYK (0.64) | SYK | |
| SCHEMBL10272204 | 0.86 | SYK (0.66) | SYK | |
| SCHEMBL10272190 | 0.83 | SYK (0.63) | SYK | |
| SCHEMBL2728643 | 0.83 | SYK (0.48) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |