Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.45 |
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.45 |
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 7/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.42 |
| ▸ | ULK1 | O75385 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30923280 | 1.00 | PTK2 (0.45) | PTK2FLT3TYRO3MERTKGAS6 | |
| SCHEMBL27290259 | 0.91 | JAK3 (0.51) | PTK2FLT3TYRO3MERTKGAS6 | |
| SCHEMBL30923225 | 0.91 | JAK3 (0.51) | PTK2FLT3TYRO3MERTKGAS6 | |
| SCHEMBL27292535 | 0.91 | CCNK (0.47) | PTK2CCNKCCNA2CDK2CCND3 | |
| SCHEMBL30923145 | 0.91 | CCNK (0.47) | PTK2CCNKCCNA2CDK2CCND3 | |
| SCHEMBL30923379 | 0.88 | PTK2 (0.49) | PTK2FLT3TYRO3MERTKGAS6 | |
| SCHEMBL27296020 | 0.88 | PTK2 (0.49) | PTK2FLT3TYRO3MERTKGAS6 | |
| SCHEMBL27292678 | 0.87 | EGFR (0.46) | PTK2CCNKCCNA2CDK2CCND3 | |
| SCHEMBL30923223 | 0.87 | EGFR (0.46) | PTK2CCNKCCNA2CDK2CCND3 | |
| SCHEMBL27292627 | 0.86 | DHODH (0.50) | PTK2CCNKCCNA2CDK2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024107658-A2 | INHIBITORS OF TYK2 | VYRNWY THERAPEUTICS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |