Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.64 |
| ▸ | CA5A | P35218 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 4/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | CFD | P00746 | 1/20 | 0.50 |
| ▸ | SELL | P14151 | 1/20 | 0.50 |
| ▸ | SELP | P16109 | 1/20 | 0.50 |
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9360555 | 0.92 | GAA (0.56) | PTGS1CA5AGAATSHRNFKB1 | |
| SCHEMBL6221035 | 0.92 | GAA (0.56) | PTGS1CA5AGAATSHRNFKB1 | |
| Methane SCHEMBL10372267 | 0.90 | GAA (0.54) | PTGS1CA5AGAATSHRNFKB1 | |
| SCHEMBL153055 | 0.88 | GAA (0.74) | PTGS1CA5AGAATSHRNFKB1 | |
| SCHEMBL30049382 | 0.88 | GAA (0.74) | PTGS1CA5AGAATSHRNFKB1 | |
| SCHEMBL27952523 | 0.86 | GAA (0.72) | PTGS1CA5AGAATSHRNFKB1 | |
| Hydrochloric Acid SCHEMBL2530820 | 0.86 | GAA (0.72) | PTGS1CA5AGAATSHRNFKB1 | |
| SCHEMBL9808605 | 0.86 | PTGS1 (0.62) | PTGS1CA5AGAATSHRNFKB1 | |
| SCHEMBL21328344 | 0.85 | GAA (0.70) | PTGS1CA5AGAATSHRNFKB1 | |
| SCHEMBL2210563 | 0.84 | RXRA (0.51) | PTGS1CA5AGAATSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9056859-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2015-06-16 | — | — | US | disclosed |
| EP-2632464-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2015-04-29 | — | — | EP | disclosed |
| EP-2632464-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| US-20130217680-A1 | Inhibitors of the Renal Outer Medullary Potassium Channel | MERCK SHARP & DOHME LLC | 2013-08-22 | — | — | US | disclosed |
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |
| US-7767854-B2 | N-substituted phenylacetamide derivative and pharmaceutical composition containing the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2010-08-03 | — | — | US | disclosed |
| US-20090192203-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2009-07-30 | — | — | US | disclosed |
| US-20090192203-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2009-07-30 | — | — | US | disclosed |
| US-20090192203-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2009-07-30 | — | — | US | disclosed |
| US-20090082463-A1 | N-substituted phenylacetamide derivative and pharmaceutical composition containing the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-03-26 | — | — | US | disclosed |
| US-20040230064-A1 | Novel labeled resiniferatoxin derivatives | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-18 | — | — | US | disclosed |
| EP-1341795-A2 | NOVEL LABELED RESINIFERATOXIN DERIVATIVES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002030937-A2 | LABELED RESINIFERATOXIN DERIVATIVES FOR USE IN VANILLOID RECEPTOR BINDING ASSAY | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-04-18 | — | — | WO | disclosed |
| EP-0535250-B1 | NOVEL COMPOUNDS AND USE THEREOF AS MEDICINE | TSUMURA & CO (JP) | 1996-06-19 | — | — | EP | disclosed |
| EP-0705817-A1 | New cannamide derivatives and their use as allergy inhibitors | TSUMURA & CO. (JP) | 1996-04-10 | — | — | EP | disclosed |
| US-5344845-A | Methyl 4(4-acetoxy-3-methoxycinnamanide and salts as an immunosuppressive drug for allergic reactions | TSUMURA & CO. (JP) | 1994-09-06 | — | — | US | disclosed |
| EP-0535250-A1 | NOVEL COMPOUNDS AND USE THEREOF AS MEDICINE | TSUMURA & CO. (JP) | 1993-04-07 | — | — | EP | disclosed |
| US-5013759-A | Phenylacetic acid amide or thioamide derivatives | THE PROCTER & GAMBLE COMPANY (US) | 1991-05-07 | — | — | US | disclosed |
| EP-0206609-B1 | COMPOUNDS AND COMPOSITIONS HAVING ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY | THE PROCTER & GAMBLE COMPANY (US) | 1989-09-20 | — | — | EP | disclosed |
| EP-0206609-A1 | Compounds and compositions having anti-inflammatory and analgesic activity | THE PROCTER & GAMBLE COMPANY (US) | 1986-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082463-A1 | N-substituted phenylacetamide derivative and pharmaceutical composition containing the same | HRH4, HRH2, CNR2 | PTGS1 5/4885CA5A 804/4885GAA 4360/4885 |
| US-20130217680-A1 | Inhibitors of the Renal Outer Medullary Potassium Channel | KCNJ11, KCNJ1, KCNJ2 | PTGS1 1496/4885CA5A 2960/4885GAA 4187/4885 |
| US-20040230064-A1 | Novel labeled resiniferatoxin derivatives | TRPV1, GPR17, ANTXR2 | PTGS1 1170/4885CA5A 3416/4885GAA 2461/4885 |
| US-20090192203-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | PPARG, PPARA, PPARD | PTGS1 354/4885CA5A 1999/4885GAA 995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.