Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.46 |
| ▸ | JAK2 | O60674 | 8/20 | 0.46 |
| ▸ | JAK1 | P23458 | 8/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.46 |
| ▸ | TYK2 | P29597 | 7/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2694157 | 0.89 | JAK3 (0.47) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2695616 | 0.89 | JAK3 (0.48) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2696531 | 0.87 | JAK3 (0.46) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2726438 | 0.87 | JAK3 (0.46) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2695414 | 0.86 | JAK3 (0.52) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2695096 | 0.85 | SYK (0.47) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2693181 | 0.85 | JAK3 (0.51) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2693949 | 0.84 | JAK3 (0.50) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2697481 | 0.82 | JAK3 (0.46) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2695093 | 0.81 | JAK3 (0.47) | JAK3JAK2JAK1IRAK4TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |