Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 16/20 | 0.45 |
| ▸ | JAK2 | O60674 | 13/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 7/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17545881 | 0.86 | JAK1 (0.47) | JAK1JAK2L3MBTL1MAPTJAK3 | |
| SCHEMBL17545962 | 0.84 | JAK1 (0.46) | JAK1JAK2L3MBTL1MAPTJAK3 | |
| SCHEMBL10227678 | 0.82 | JAK1 (0.48) | JAK1JAK2L3MBTL1MAPTHTR6 | |
| SCHEMBL10228627 | 0.82 | JAK1 (0.48) | JAK1JAK2L3MBTL1MAPTHTR6 | |
| SCHEMBL10227681 | 0.82 | JAK1 (0.48) | JAK1JAK2L3MBTL1ATRATRIP | |
| SCHEMBL2731818 | 0.80 | JAK2 (0.43) | JAK1JAK2L3MBTL1ATRATRIP | |
| SCHEMBL17500868 | 0.80 | JAK1 (0.46) | JAK1JAK2L3MBTL1JAK3TYK2 | |
| SCHEMBL17500867 | 0.80 | JAK1 (0.46) | JAK1JAK2L3MBTL1JAK3TYK2 | |
| SCHEMBL15972409 | 0.79 | JAK1 (0.48) | JAK1JAK2L3MBTL1JAK3TYK2 | |
| SCHEMBL21351639 | 0.79 | JAK1 (0.46) | JAK1JAK2L3MBTL1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632898-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | Biogen Idec MA Inc. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058645-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2012-05-03 | — | — | WO | disclosed |