SCHEMBL27299157

SCHEMBL27299157

Cn1cnnc1-c1ccncc1-c1cc(NC2(CC#N)CC2)nc(N2Cc3c(cc(CN4CC5(CCOC5)C4)cc3C(F)(F)F)C2=O)c1

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 20/20 0.46
▸ CBLC Q9ULV8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27296643 0.92 CBLB (0.46) CBLB
SCHEMBL27293162 0.92 CBLB (0.49) CBLB
SCHEMBL27297159 0.91 CBLB (0.52) CBLBCBLC
SCHEMBL27299155 0.90 CBLB (0.47) CBLB
SCHEMBL27299512 0.86 CBLB (0.44) CBLB
SCHEMBL27328612 0.86 CBLB (0.44) CBLB
SCHEMBL27294820 0.85 CBLB (0.52) CBLB
SCHEMBL27299814 0.83 CBLB (0.47) CBLB
SCHEMBL27327742 0.83 CBLB (0.48) CBLB
SCHEMBL27294883 0.83 CBLB (0.55) CBLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024081311-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2024-04-18 — — WO disclosed
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