SCHEMBL2730971

SCHEMBL2730971

COCCC1CCCC1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.44
RAB9A P51151 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
LMNA P02545 1/20 0.44
CA1 P00915 4/20 0.41
CA2 P00918 4/20 0.41
CA4 P22748 4/20 0.41
CA6 P23280 3/20 0.41
GAA P10253 1/20 0.40
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
KDM4E B2RXH2 1/20 0.38
PTGS1 P23219 3/20 0.36
PTGS2 P35354 3/20 0.36
OPRK1 P41145 1/20 0.36
HTT P42858 1/20 0.36
KMT2A Q03164 1/20 0.36
PSEN1 P49768 1/20 0.33
PSEN2 P49810 1/20 0.33
APH1B Q8WW43 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL728940 0.94 CA1 (0.46) NPC1RAB9ASMN1; SMN2LMNACA1
SCHEMBL14720529 0.79
SCHEMBL27371972 0.79
SCHEMBL4347324 0.78 NPC1 (0.47) NPC1RAB9ASMN1; SMN2LMNACA1
SCHEMBL2691566 0.77
SCHEMBL9513383 0.77 NPC1 (0.39) NPC1RAB9ASMN1; SMN2LMNACA1
SCHEMBL8615642 0.76 NPC1 (0.46) NPC1RAB9ASMN1; SMN2LMNACA1
SCHEMBL29852107 0.74 NPC1 (0.49) NPC1RAB9ASMN1; SMN2LMNACA1
SCHEMBL11763977 0.74 NPC1 (0.54) NPC1RAB9ASMN1; SMN2LMNACA1
SCHEMBL6706718 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2632454-A1 HIV INTEGRASE INHIBITORS Merck Sharp & Dohme Corp. (US) 2013-09-04 EP disclosed
WO-2012058173-A1 HIV INTEGRASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2012-05-03 WO disclosed
WO-2012058173-A1 HIV INTEGRASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2012-05-03 WO disclosed
US-4439365-A TRIPHENYLMETHOXY ALKENYLMAGNESIUM HALIDES AMERICAN CYANAMID COMPANY (US) 1984-03-27 US disclosed
US-4343949-A PROSTAGLANDIN REARRANGEMENTS AMERICAN CYANAMID COMPANY (US) 1982-08-10 US disclosed
US-4180677-A Novel prostaglandins AMERICAN CYANAMID COMPANY (US) 1979-12-25 US disclosed
US-4179574-A PROSTAGLANDIN INTERMEDIATES AMERICAN CYANAMID COMPANY (US) 1979-12-18 US disclosed
US-4123456-A BRONCHODILATORS, HYPOTENSIVES, ANTIULCER, ANTISECRETORY, MICROBIOCIDES, ANTICONVULSANTS, OXYTOCICS, ANALGESICS, DIURETICS, ANTIINFLAMMATORY, ANTICOAGULANTS AMERICAN CYANAMID COMPANY (US) 1978-10-31 US disclosed
US-4110368-A PROSTAGLANDINS, BRONCHODILATOR, ANTIULCER AMERICAN CYANAMID COMPANY (US) 1978-08-29 US disclosed
US-4060540-A BRONCHODILATORS, HYPOTENSIVE, ANTIULCER AMERICAN CYANAMID COMPANY (US) 1977-11-29 US disclosed
US-4007210-A PROSTANOIC ACID DERIVATIVES AMERICAN CYANAMID COMPANY (US) 1977-02-08 US disclosed
US-3993674-A ANTIULCER, BRONCHODILATOR, HYPOTENSIVE AMERICAN CYANAMID COMPANY (US) 1976-11-23 US disclosed
US-3966773-A BRONCHODILATOR, HYPOTENSIVE, ANTIULCER AMERICAN CYANAMID COMPANY (US) 1976-06-29 US disclosed
US-3932479-A BRONCHODILATOR, HYPOTENSIVE, ANTIULCER AMERICAN CYANAMID COMPANY (US) 1976-01-13 US disclosed