SCHEMBL27312417

SCHEMBL27312417

Cn1cc(-c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)nc1-c1cccc(-c2ccccc2)c1

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 9/20 0.53
▸ IKZF1 Q13422 3/20 0.51
▸ CSNK1A1 P48729 2/20 0.51
▸ IKZF2 Q9UKS7 8/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27312418 0.96 CRBN (0.55) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27216923 0.95 CRBN (0.56) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL30801574 0.95 CRBN (0.56) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27216986 0.95 CRBN (0.56) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27325224 0.93 CRBN (0.56) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27326991 0.91 CRBN (0.61) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27311580 0.91 CRBN (0.53) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27327237 0.90 CRBN (0.53) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27325298 0.89 CRBN (0.49) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL30801575 0.89 CRBN (0.53) CRBNIKZF1CSNK1A1IKZF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024054832-A1 CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. (US) 2024-03-14 — — WO disclosed
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