Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.70 |
| ▸ | POLB | P06746 | 8/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sumiki'S Acid SCHEMBL29706392 | 0.83 | TDP1 (1.00) | TDP1POLBSMN1; SMN2NPC1RAB9A | |
| Sumiki'S Acid SCHEMBL50822 | 0.83 | TDP1 (1.00) | TDP1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL27381621 | 0.82 | TDP1 (0.62) | TDP1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13841169 | 0.82 | TDP1 (0.62) | TDP1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL17016712 | 0.82 | TDP1 (0.47) | TDP1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL27484038 | 0.82 | TDP1 (0.62) | TDP1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL17537931 | 0.82 | TDP1 (0.62) | TDP1POLBSMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL901472 | 0.80 | TDP1 (0.72) | TDP1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL24401235 | 0.80 | TDP1 (0.60) | TDP1POLBNPC1RAB9AL3MBTL1 | |
| Ethylene Glycol SCHEMBL20377334 | 0.80 | TDP1 (0.64) | TDP1POLBL3MBTL1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1048493-C | 06-substituted guanine derivatives, a process for their prepn. and their use | CANCER RES CAMPAIGN TECH (GB) | 2000-01-19 | — | — | CN | disclosed |
| CN-1145622-A | O 6Substituted guanine derivatives, process for their preparation and their use | CANCER RES CAMPAIGN TECH (GB) | 1997-03-19 | — | — | CN | disclosed |