Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 15/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL729535 | 0.80 | DHODH (0.84) | DHODH | |
| SCHEMBL1955242 | 0.76 | DHODH (0.78) | DHODH | |
| SCHEMBL729551 | 0.73 | DHODH (1.00) | DHODH | |
| SCHEMBL729529 | 0.72 | DHODH (1.00) | DHODH | |
| SCHEMBL2730244 | 0.68 | DHODH (0.57) | DHODHAKR1C3AKR1C2 | |
| SCHEMBL15712711 | 0.67 | DHODH (0.60) | DHODH | |
| SCHEMBL15712406 | 0.67 | DHODH (0.60) | DHODH | |
| SCHEMBL729458 | 0.65 | DHODH (1.00) | DHODH | |
| SCHEMBL727460 | 0.65 | DHODH (0.83) | DHODH | |
| SCHEMBL3732615 | 0.65 | DHODH (0.74) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052180-A1 | COMBINATIONS COMPRISING DHODH INHIBITORS AND COX INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-26 | — | — | WO | disclosed |