Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | WEE1 | P30291 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | SIK1 | P57059 | 1/20 | 0.42 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.42 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30962653 | 1.00 | LCK (0.48) | LCKKDRJAK3TEKMAPK14 | |
| SCHEMBL30962905 | 0.93 | LCK (0.50) | LCKKDRJAK3TEKMAPK14 | |
| SCHEMBL27313423 | 0.89 | LCK (0.51) | LCKKDRJAK3TEKMAPK14 | |
| SCHEMBL30962770 | 0.89 | LCK (0.51) | LCKKDRJAK3TEKMAPK14 | |
| SCHEMBL30962656 | 0.89 | WEE1 (0.49) | LCKKDRJAK3TEKMAPK14 | |
| SCHEMBL27313755 | 0.89 | SIK1 (0.44) | LCKKDRJAK3TEKMAPK14 | |
| SCHEMBL30962584 | 0.89 | SIK1 (0.44) | LCKKDRJAK3TEKMAPK14 | |
| SCHEMBL30962624 | 0.89 | WEE1 (0.52) | LCKKDRJAK3TEKMAPK14 | |
| SCHEMBL27313552 | 0.89 | WEE1 (0.52) | LCKKDRJAK3TEKMAPK14 | |
| SCHEMBL30962827 | 0.88 | LCK (0.52) | LCKKDRJAK3TEKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024145505-A1 | PYRIMIDINE CARBOXAMIDE COMPOUNDS | ACRIVON THERAPEUTICS, INC. (US) | 2024-07-04 | — | — | WO | disclosed |