Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Propionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 6/20 | 0.32 |
| ▸ | PPARD | Q03181 | 6/20 | 0.32 |
| ▸ | PPARA | Q07869 | 6/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL7459031 | 1.00 | FFAR3 (0.62) | FFAR3ALDH1A1TDP1LCKFYN | |
| Propionic Acid SCHEMBL9619152 | 0.94 | FFAR3 (0.71) | FFAR3ALDH1A1TDP1HDAC3HDAC1 | |
| Propionic Acid SCHEMBL15260565 | 0.94 | FFAR3 (0.71) | FFAR3ALDH1A1TDP1HDAC3HDAC1 | |
| Propionic Acid SCHEMBL1258739 | 0.94 | — | — | |
| Propionic Acid SCHEMBL5342228 | 0.94 | FFAR3 (0.71) | FFAR3ALDH1A1TDP1HDAC3HDAC1 | |
| Propionic Acid SCHEMBL27672329 | 0.94 | FFAR3 (0.71) | FFAR3ALDH1A1TDP1HDAC3HDAC1 | |
| Propionic Acid SCHEMBL9619149 | 0.94 | FFAR3 (0.71) | FFAR3ALDH1A1TDP1HDAC3HDAC1 | |
| Propionic Acid SCHEMBL5689701 | 0.89 | FFAR3 (0.50) | FFAR3ALDH1A1TDP1LCKFYN | |
| Propionic Acid SCHEMBL19458358 | 0.88 | FFAR3 (0.62) | FFAR3ALDH1A1TDP1HDAC3HDAC1 | |
| Benzene SCHEMBL2386401 | 0.88 | FFAR3 (0.62) | FFAR3ALDH1A1TDP1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1032212-C | N-protected alpha-L-aspartyl-L-methyl phenylalaninate | MITSUI TOATSU CHEMICALS (JP) | 1996-07-03 | — | — | CN | disclosed |