Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20885450 | 0.88 | KDM2B (0.41) | HRH3CYP2D6KCNH2KDM2B | |
| SCHEMBL26347706 | 0.88 | KDM2B (0.41) | HRH3CYP2D6KCNH2KDM2B | |
| SCHEMBL22305194 | 0.87 | HRH3 (0.38) | HRH3CYP2D6KCNH2 | |
| SCHEMBL21779855 | 0.79 | HRH3 (0.42) | HRH3CYP2D6KCNH2KDM2B | |
| SCHEMBL14265647 | 0.79 | HRH3 (0.42) | HRH3CYP2D6KCNH2KDM2B | |
| SCHEMBL27420755 | 0.79 | HRH3 (0.42) | HRH3CYP2D6KCNH2KDM2B | |
| SCHEMBL22152206 | 0.79 | HRH3 (0.33) | HRH3CYP2D6KCNH2 | |
| SCHEMBL22152651 | 0.76 | HRH3 (0.32) | HRH3 | |
| SCHEMBL12258806 | 0.75 | MAPT (0.44) | HRH3KDM2B | |
| SCHEMBL7882719 | 0.75 | MAPT (0.44) | HRH3KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024076672-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |