SCHEMBL27318330

SCHEMBL27318330

COc1c(F)cccc1-c1c(-c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)ncn1C

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 8/20 0.47
▸ IKZF2 Q9UKS7 9/20 0.46
▸ IKZF1 Q13422 3/20 0.45
▸ CSNK1A1 P48729 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27319364 0.91 CRBN (0.50) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27318235 0.89 CRBN (0.47) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27319734 0.89 CRBN (0.50) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27318230 0.88 IKZF2 (0.50) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27319178 0.87 CRBN (0.52) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27318242 0.87 IKZF2 (0.49) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27317877 0.87 CRBN (0.49) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27318239 0.86 CRBN (0.48) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27318328 0.86 CRBN (0.48) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27317873 0.86 CRBN (0.52) CRBNIKZF2IKZF1CSNK1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024054832-A1 CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. (US) 2024-03-14 — — WO disclosed
Send feedback