Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 5/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.39 |
| ▸ | LAP3 | P28838 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6034381 | 1.00 | ANPEP (0.42) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| SCHEMBL27422167 | 1.00 | ANPEP (0.42) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| SCHEMBL30589985 | 0.78 | ANPEP (0.44) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| SCHEMBL9294910 | 0.78 | SLC22A6 (0.36) | LMNASLC22A6 | |
| SCHEMBL28794128 | 0.78 | SLC22A6 (0.36) | LMNASLC22A6 | |
| SCHEMBL15980620 | 0.78 | ANPEP (0.44) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| SCHEMBL356000 | 0.77 | S1PR2 (0.41) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| SCHEMBL354858 | 0.77 | S1PR2 (0.41) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| SCHEMBL355325 | 0.77 | S1PR2 (0.41) | ANPEPERAP1ERAP2TSHRCYP3A4 | |
| Isopropylamine SCHEMBL27887484 | 0.77 | SLC22A6 (0.39) | ANPEPERAP1TSHRLMNASLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046512-C | Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace | MERRELL DOW PHARMA (US) | 1999-11-17 | — | — | CN | claimed |
| CN-1069317-C | Novel indane-2-mercaptoacetylamide disulfide derivs. useful as inhibitors of enkephalinase | MERRELL PHARMA INC (US) | 2001-08-08 | — | — | CN | disclosed |
| CN-1046512-C | Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace | MERRELL DOW PHARMA (US) | 1999-11-17 | — | — | CN | disclosed |
| CN-1142826-A | Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace | MERRELL DOW PHARMA (US) | 1997-02-12 | — | — | CN | disclosed |
| CN-1142831-A | Novel 2-substituted indane-2-mercaploacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace | MERRELL DOW PHARMA (US) | 1997-02-12 | — | — | CN | disclosed |
| CN-1140451-A | Novel 1, 2-indan-2-mercaptoacetamide disulfide derivatives as enkephalinase inhibitors | MERRELL DOW PHARMA (US) | 1997-01-15 | — | — | CN | disclosed |