Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 5/20 | 0.44 |
| ▸ | BRAF | P15056 | 7/20 | 0.40 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39823 | 0.93 | SLC34A2 (0.46) | CHRM3BRAFSLC34A2HRH4RAF1 | |
| SCHEMBL40137 | 0.88 | CHRM3 (0.43) | CHRM3BRAFSLC34A2HRH4RAF1 | |
| SCHEMBL40112 | 0.88 | SLC34A2 (0.48) | BRAFSLC34A2HRH4RAF1KDM4E | |
| SCHEMBL46678 | 0.85 | SLC34A2 (0.48) | CHRM3BRAFSLC34A2HRH4RAF1 | |
| SCHEMBL40118 | 0.84 | CHRM3 (0.43) | CHRM3SLC34A2ROCK2KDM1AHDAC1 | |
| SCHEMBL15432568 | 0.84 | SLC34A2 (0.45) | BRAFSLC34A2HRH4RAF1KDM4E | |
| SCHEMBL46676 | 0.83 | SLC34A2 (0.43) | BRAFSLC34A2HRH4RAF1DDR2 | |
| SCHEMBL39969 | 0.83 | SLC34A2 (0.45) | BRAFSLC34A2HRH4RAF1KDM4E | |
| SCHEMBL19596316 | 0.83 | CHRM3 (0.42) | CHRM3BRAFSLC34A2HRH4RAF1 | |
| SCHEMBL18059165 | 0.82 | CHRM3 (0.45) | CHRM3BRAFSLC34A2HRH4RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |