Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14206459 | 0.89 | CHEK1 (0.54) | CHEK1IRAK4PIM1PIM3PIM2 | |
| SCHEMBL2732793 | 0.87 | CHEK1 (0.53) | CHEK1IRAK4PIM1PIM3PIM2 | |
| SCHEMBL14206493 | 0.86 | CHEK1 (0.53) | CHEK1IRAK4 | |
| SCHEMBL2732556 | 0.86 | CHEK1 (0.59) | CHEK1IRAK4 | |
| SCHEMBL2730170 | 0.86 | CHEK1 (0.51) | CHEK1IRAK4 | |
| SCHEMBL2729045 | 0.86 | CHEK1 (0.51) | CHEK1IRAK4PIM1PIM3PIM2 | |
| SCHEMBL14206469 | 0.85 | CHEK1 (0.56) | CHEK1IRAK4LMNA | |
| SCHEMBL2731268 | 0.85 | CHEK1 (0.57) | CHEK1IRAK4 | |
| SCHEMBL2731832 | 0.84 | CHEK1 (0.56) | CHEK1IRAK4 | |
| SCHEMBL14206467 | 0.84 | CHEK1 (0.51) | CHEK1IRAK4PIM1LMNAPIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632263-A1 | NOVEL THIAZOLE-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | claimed |
| WO-2012058174-A1 | NOVEL THIAZOLE-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | SCHERING CORPORATION (US) | 2012-05-03 | — | — | WO | claimed |
| EP-2632263-A1 | NOVEL THIAZOLE-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058174-A1 | NOVEL THIAZOLE-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | SCHERING CORPORATION (US) | 2012-05-03 | — | — | WO | disclosed |