Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.59 |
| ▸ | LCK | P06239 | 9/20 | 0.48 |
| ▸ | BTK | Q06187 | 7/20 | 0.48 |
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | SYK | P43405 | 4/20 | 0.46 |
| ▸ | STAT6 | P42226 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714179 | 0.96 | JAK3 (0.57) | JAK3LCKBTKEGFRSYK | |
| SCHEMBL2712825 | 0.87 | JAK3 (0.59) | JAK3LCKBTKEGFRSYK | |
| SCHEMBL2715004 | 0.87 | JAK3 (0.61) | JAK3LCKBTKEGFRSYK | |
| SCHEMBL2693964 | 0.86 | JAK3 (0.56) | JAK3LCKBTKEGFRSYK | |
| SCHEMBL2697776 | 0.86 | JAK3 (0.61) | JAK3LCKBTKEGFRSYK | |
| SCHEMBL2694969 | 0.85 | JAK3 (0.55) | JAK3LCKBTKEGFRSYK | |
| SCHEMBL2696029 | 0.84 | JAK3 (0.56) | JAK3LCKBTKEGFRSYK | |
| SCHEMBL2695407 | 0.83 | JAK3 (0.55) | JAK3LCKBTKEGFRSYK | |
| SCHEMBL2693539 | 0.83 | JAK3 (0.58) | JAK3LCKBTKEGFRSYK | |
| SCHEMBL2693638 | 0.83 | JAK3 (0.58) | JAK3LCKBTKEGFRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |