Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 16/20 | 0.60 |
| ▸ | PIM1 | P11309 | 14/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 12/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732278 | 1.00 | PIM2 (0.60) | PIM2PIM1PIM3CHEK1IRAK4 | |
| SCHEMBL790529 | 0.87 | PIM1 (0.52) | PIM2PIM1PIM3CHEK1IRAK4 | |
| SCHEMBL790528 | 0.87 | PIM1 (0.52) | PIM2PIM1PIM3CHEK1IRAK4 | |
| SCHEMBL2728704 | 0.85 | CHEK1 (0.56) | PIM2PIM1PIM3CHEK1IRAK4 | |
| SCHEMBL10184985 | 0.85 | PIM2 (0.59) | PIM2PIM1PIM3 | |
| SCHEMBL807609 | 0.85 | CHEK1 (0.51) | PIM2PIM1PIM3CHEK1IRAK4 | |
| SCHEMBL2731037 | 0.83 | PIM1 (0.57) | PIM2PIM1PIM3 | |
| SCHEMBL15052300 | 0.83 | PIM2 (0.57) | PIM2PIM1PIM3 | |
| SCHEMBL797658 | 0.83 | PIM2 (0.57) | PIM2PIM1PIM3 | |
| SCHEMBL2731474 | 0.83 | PIM1 (0.57) | PIM2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632462-A1 | NOVEL HETEROARYL-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058176-A1 | NOVEL HETEROARYL-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | SCHERING CORPORATION (US) | 2012-05-03 | — | — | WO | disclosed |