Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | F2R | P25116 | 1/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | PYGB | P11216 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5949330 | 1.00 | TSHR (0.39) | TSHREPHX1GLAMAPTBTK | |
| SCHEMBL15014513 | 0.85 | EPHX1 (0.43) | TSHREPHX1MAPTBTKALDH1A1 | |
| SCHEMBL23379074 | 0.85 | EPHX1 (0.43) | TSHREPHX1MAPTBTKALDH1A1 | |
| SCHEMBL12425824 | 0.85 | EPHX1 (0.43) | TSHREPHX1MAPTBTKALDH1A1 | |
| SCHEMBL14864808 | 0.85 | EPHX1 (0.43) | TSHREPHX1MAPTBTKALDH1A1 | |
| SCHEMBL8156249 | 0.82 | TSHR (0.39) | TSHREPHX1 | |
| SCHEMBL12437109 | 0.79 | MAPT (0.41) | TSHREPHX1GLAMAPTBTK | |
| SCHEMBL23772481 | 0.79 | BTK (0.47) | TSHREPHX1GLAMAPTBTK | |
| SCHEMBL22722033 | 0.79 | MAPT (0.41) | TSHREPHX1GLAMAPTBTK | |
| SCHEMBL23917856 | 0.79 | BTK (0.47) | TSHREPHX1GLAMAPTBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024123966-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |
| WO-2024124002-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |