Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 3/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452498 | 0.74 | HDAC1 (0.42) | PIK3C3 | |
| SCHEMBL6883044 | 0.73 | NOTUM (0.44) | NOTUMIDH1L3MBTL1MAPTP2RX7 | |
| SCHEMBL6871051 | 0.73 | NOTUM (0.44) | NOTUMIDH1L3MBTL1MAPTP2RX7 | |
| SCHEMBL8585033 | 0.73 | NOTUM (0.44) | NOTUMIDH1L3MBTL1MAPTP2RX7 | |
| SCHEMBL22771081 | 0.72 | NOTUM (0.39) | NOTUMIDH1 | |
| SCHEMBL14313872 | 0.71 | PIK3C3 (0.48) | IDH1KDM4EPIK3C3 | |
| SCHEMBL22771266 | 0.71 | NOTUM (0.40) | NOTUMIDH1 | |
| SCHEMBL13278809 | 0.70 | IDH1 (0.39) | IDH1 | |
| SCHEMBL22771269 | 0.70 | NOTUM (0.37) | NOTUMIDH1 | |
| SCHEMBL30738483 | 0.68 | GSK3B (0.39) | AKR1C3TDP1L3MBTL1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632269-A1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058187-A1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |
| EP-2029560-A2 | 1,3-OXAZOLIDIN-2-ONE DERIVATIVES USEEFUL AS CETP INHIBITORS | Merck & Co., Inc. (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007079186-A2 | 1, 3-OXAZOLIDIN-2-ONE DERIVATIVES USEFUL AS CETP INHIBITORS | MERCK & CO., INC. (US) | 2007-07-12 | — | — | WO | disclosed |