Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NRAS | P01111 | 12/20 | 0.42 |
| ▸ | FLT3 | P36888 | 12/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.39 |
| ▸ | CDK7 | P50613 | 3/20 | 0.39 |
| ▸ | CCNH | P51946 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 6/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27327896 | 1.00 | NRAS (0.42) | NRASFLT3IRAK1CDK7CCNH | |
| SCHEMBL31739753 | 0.93 | FLT3 (0.41) | NRASFLT3IRAK1CDK7CCNH | |
| SCHEMBL27327391 | 0.93 | FLT3 (0.41) | NRASFLT3IRAK1CDK7CCNH | |
| SCHEMBL31739607 | 0.93 | FLT3 (0.41) | NRASFLT3IRAK1CDK7CCNH | |
| SCHEMBL27330141 | 0.93 | FLT3 (0.41) | NRASFLT3IRAK1CDK7CCNH | |
| SCHEMBL27329941 | 0.93 | FLT3 (0.41) | NRASFLT3IRAK1CDK7CCNH | |
| SCHEMBL27327561 | 0.93 | FLT3 (0.41) | NRASFLT3IRAK1CDK7CCNH | |
| SCHEMBL27327101 | 0.93 | FLT3 (0.38) | NRASFLT3IRAK1CDK7CCNH | |
| SCHEMBL27331053 | 0.93 | FLT3 (0.38) | NRASFLT3IRAK1CDK7CCNH | |
| SCHEMBL27328041 | 0.90 | FLT3 (0.46) | NRASFLT3IRAK1CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023245123-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-12-21 | — | — | WO | disclosed |