Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16019477 | 0.83 | POLB (0.31) | POLB | |
| SCHEMBL16019489 | 0.80 | — | — | |
| SCHEMBL27270856 | 0.72 | TLR9 (0.36) | PDE10A | |
| SCHEMBL15931984 | 0.66 | CNR2 (0.41) | PIK3CG | |
| SCHEMBL23082927 | 0.65 | POLB (0.30) | POLB | |
| SCHEMBL286091 | 0.62 | PDE1C (0.36) | — | |
| SCHEMBL15934087 | 0.62 | CHRM2 (0.41) | PIK3CG | |
| SCHEMBL23062918 | 0.61 | — | — | |
| SCHEMBL3588521 | 0.61 | PIK3C3 (0.38) | PIK3CG | |
| SCHEMBL11295038 | 0.60 | GAA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024076672-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |