Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.58 |
| ▸ | BCR | P11274 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2378488 | 0.84 | KMT2A (0.61) | KMT2AALDH1A1PIK3CAMTORMAPT | |
| SCHEMBL8318298 | 0.82 | EGFR (0.71) | ABL1BCREGFRALDH1A1CYP1A2 | |
| SCHEMBL27319619 | 0.80 | SMN1; SMN2 (0.63) | ABL1BCRKMT2AEGFRTNNI3K | |
| SCHEMBL2174721 | 0.80 | EGFR (0.64) | KMT2AEGFRTNNI3KALDH1A1MAPT | |
| SCHEMBL8316766 | 0.79 | EGFR (0.74) | EGFRPIK3CAMTORMAPTPOLB | |
| SCHEMBL4771812 | 0.78 | MAP3K8 (0.69) | EGFR | |
| SCHEMBL5903469 | 0.77 | POLB (0.66) | KMT2AALDH1A1MAPTMEN1HTT | |
| SCHEMBL8809069 | 0.77 | ABL1 (0.68) | ABL1BCREGFRALDH1A1CYP1A2 | |
| SCHEMBL13771534 | 0.76 | ABL1 (0.70) | ABL1BCRKMT2AEGFRALDH1A1 | |
| SCHEMBL28288635 | 0.76 | JAK2 (0.64) | KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |