Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.65 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.58 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2134955 | 0.86 | S1PR1 (0.74) | S1PR1S1PR3S1PR5 | |
| SCHEMBL2134641 | 0.85 | S1PR1 (0.63) | S1PR1S1PR3S1PR5 | |
| SCHEMBL2135761 | 0.85 | S1PR1 (0.82) | S1PR1S1PR3S1PR5 | |
| SCHEMBL2131667 | 0.84 | S1PR1 (0.59) | S1PR1S1PR3S1PR5 | |
| SCHEMBL3420904 | 0.84 | S1PR1 (0.67) | S1PR1S1PR3S1PR5 | |
| SCHEMBL2133258 | 0.84 | S1PR1 (0.67) | S1PR1S1PR3S1PR5 | |
| SCHEMBL2138549 | 0.84 | S1PR1 (0.63) | S1PR1S1PR3S1PR5 | |
| SCHEMBL2718080 | 0.83 | S1PR1 (0.80) | S1PR1S1PR3S1PR5 | |
| SCHEMBL3417653 | 0.83 | S1PR1 (0.72) | S1PR1S1PR3S1PR5 | |
| SCHEMBL2136271 | 0.83 | S1PR1 (0.72) | S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445891-A1 | 5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010148649-A1 | 5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2010-12-29 | — | — | WO | disclosed |