SCHEMBL27338643

SCHEMBL27338643

COC(=O)N1CC(c2nc(-c3ccc(C)c(NC(=O)c4cnc5ccc(OC(C)CO)cn45)c3)no2)C1

nearest known ligand 0.62

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27338942 0.91 KIT (0.68) KIT
SCHEMBL14740245 0.91 KIT (0.66) KIT
SCHEMBL27339229 0.90 KIT (0.63) KIT
SCHEMBL14740425 0.88 KIT (0.77) KIT
SCHEMBL14739399 0.88 KIT (0.77) KIT
SCHEMBL14752834 0.86 KIT (0.70) KIT
SCHEMBL14742075 0.86 KIT (0.67) KIT
SCHEMBL21387496 0.86 KIT (0.66) KIT
SCHEMBL14740265 0.86 KIT (0.79) KIT
SCHEMBL14752785 0.86 KIT (0.66) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024124002-A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS THIRD HARMONIC BIO, INC. (US) 2024-06-13 WO disclosed