Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RHOA | P61586 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | CFD | P00746 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27332161 | 0.87 | JAK3 (0.58) | EGFRJAK3MEN1NPC1RAB9A | |
| SCHEMBL27319709 | 0.84 | EGFR (0.58) | EGFRJAK3MEN1NPC1RAB9A | |
| SCHEMBL27318793 | 0.83 | EGFR (0.67) | EGFRJAK3TNNI3KMEN1NPC1 | |
| SCHEMBL27523685 | 0.82 | EGFR (0.51) | EGFRJAK3MAPTMAPK1MAP4K4 | |
| SCHEMBL27332169 | 0.82 | EGFR (0.51) | EGFRJAK3MEN1NPC1RAB9A | |
| SCHEMBL27408584 | 0.81 | EGFR (0.52) | EGFRJAK3TNNI3KMEN1NPC1 | |
| SCHEMBL27344277 | 0.81 | JAK3 (0.52) | EGFRJAK3ERBB3RHOACFD | |
| SCHEMBL27321748 | 0.81 | EGFR (0.46) | EGFRJAK3TNNI3KMEN1NPC1 | |
| SCHEMBL27345372 | 0.80 | EGFR (0.46) | EGFRJAK3TNNI3KMEN1NPC1 | |
| SCHEMBL27401062 | 0.80 | EGFR (0.49) | EGFRJAK3TNNI3KMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |