Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 8/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | DHODH | Q02127 | 8/20 | 0.40 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2725531 | 0.92 | GCK (0.38) | GCKKCNH2DHODHKIFC1KDM4E | |
| SCHEMBL9897475 | 0.91 | GCK (0.49) | GCKKCNH2KIFC1 | |
| SCHEMBL2726219 | 0.87 | GCK (0.41) | GCKKCNH2KDM4EMAPTALDH1A1 | |
| SCHEMBL2725891 | 0.87 | GCK (0.44) | GCKKCNH2KDM4EMAPTALDH1A1 | |
| SCHEMBL9899104 | 0.84 | GCK (0.46) | GCKKCNH2 | |
| SCHEMBL2726593 | 0.82 | GCK (0.41) | GCKKCNH2 | |
| SCHEMBL1270761 | 0.81 | KDM4E (0.38) | DHODHKIFC1KDM4EMAPTALDH1A1 | |
| SCHEMBL1271151 | 0.81 | GCK (0.41) | GCKKCNH2 | |
| SCHEMBL2728096 | 0.80 | GCK (0.46) | GCKKCNH2KDM4EMAPTALDH1A1 | |
| SCHEMBL2724942 | 0.80 | GCK (0.47) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445908-A1 | DISUBSTITUTED BENZAMIDE DERIVATIVES AS GLUCOKINASE (GK) ACTIVATORS | Cadila Healthcare Limited (IN) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010150280-A1 | DISUBSTITUTED BENZAMIDE DERIVATIVES AS GLUCOKINASE (GK) ACTIVATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-12-29 | — | — | WO | disclosed |