Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 10/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733119 | 0.85 | BTK (0.44) | BTK | |
| SCHEMBL15248283 | 0.71 | FGFR3 (0.46) | BTK | |
| SCHEMBL16025986 | 0.69 | AXL (0.42) | DRD2TYRO3ALK | |
| SCHEMBL16025543 | 0.68 | AXL (0.41) | DRD2ALK | |
| SCHEMBL16025985 | 0.67 | LRRK2 (0.49) | — | |
| SCHEMBL30084116 | 0.67 | PTGER1 (0.38) | BTK | |
| SCHEMBL30084130 | 0.67 | PTGER1 (0.38) | — | |
| SCHEMBL173515 | 0.67 | PTGER1 (0.38) | BTK | |
| SCHEMBL2732363 | 0.67 | DCLK1 (0.40) | — | |
| SCHEMBL2733380 | 0.67 | MKNK1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632268-A2 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058127-A2 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-05-03 | — | — | WO | disclosed |