SCHEMBL27345807

SCHEMBL27345807

COc1ccc(Br)cc1SNc1noc2cc(Cn3cccn3)cc(OC)c12

nearest known ligand 0.61

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ KAT7 O95251 20/20 0.61
▸ KAT6A Q92794 20/20 0.61
▸ KAT6B Q8WYB5 14/20 0.61
▸ KAT5 Q92993 14/20 0.61
▸ KAT8 Q9H7Z6 14/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27343885 0.88 KAT7 (0.61) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL24866159 0.87 KAT7 (0.56) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL27345139 0.86 KAT7 (0.59) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL27345076 0.84 KAT7 (0.58) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22817402 0.84 KAT7 (0.68) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL24866164 0.84 KAT7 (0.53) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL24866171 0.82 KAT7 (0.56) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL22802508 0.81 KAT7 (0.83) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30680835 0.81 KAT7 (0.83) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL24866153 0.81 KAT6A (0.55) KAT7KAT6AKAT6BKAT5KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023245150-A1 KAT6 TARGETING COMPOUNDS WITH UBIQUITIN LIGASE BINDING MOIETY PRELUDE THERAPEUTICS INCORPORATED (US) 2023-12-21 — — WO disclosed
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