Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.64 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.64 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 5/20 | 0.51 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | IL1B | P01584 | 1/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26835997 | 1.00 | CRBN (0.64) | CRBNDDB1STAT3MAP1LC3BJAK2 | |
| SCHEMBL27347502 | 1.00 | CRBN (0.64) | CRBNDDB1STAT3MAP1LC3BJAK2 | |
| SCHEMBL22289929 | 1.00 | CRBN (0.64) | CRBNDDB1STAT3MAP1LC3BJAK2 | |
| SCHEMBL27347266 | 0.99 | CRBN (0.65) | CRBNDDB1STAT3MAP1LC3BJAK2 | |
| SCHEMBL30993171 | 0.97 | CRBN (0.65) | CRBNDDB1STAT3MAP1LC3BJAK2 | |
| SCHEMBL19606405 | 0.97 | CRBN (0.65) | CRBNDDB1STAT3MAP1LC3BJAK2 | |
| SCHEMBL23729386 | 0.94 | CRBN (0.72) | CRBNDDB1STAT3MAP1LC3BAXL | |
| SCHEMBL30638304 | 0.93 | CRBN (0.59) | CRBNDDB1STAT3MAP1LC3BAXL | |
| SCHEMBL26815430 | 0.91 | STAT3 (0.65) | CRBNDDB1STAT3MAP1LC3BIKZF1 | |
| SCHEMBL22580794 | 0.91 | CRBN (0.56) | CRBNDDB1MAP1LC3BBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024138128-A2 | CEREBLON DEGRADER CONJUGATES, AND USES THEREOF | GENENTECH, INC. (US) | 2024-06-27 | — | — | WO | disclosed |