Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.61 |
| ▸ | ACLY | P53396 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 5/20 | 0.43 |
| ▸ | CA1 | P00915 | 5/20 | 0.43 |
| ▸ | CA2 | P00918 | 5/20 | 0.43 |
| ▸ | CA4 | P22748 | 5/20 | 0.43 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184182 | 0.93 | BCL2 (0.73) | BCL2ACLYTP53CA12CA1 | |
| SCHEMBL184783 | 0.86 | BCL2 (0.79) | BCL2ACLYTP53SLC2A1TAS2R14 | |
| SCHEMBL2735099 | 0.81 | BCL2 (0.70) | BCL2ACLYTP53SLC2A1TAS2R14 | |
| SCHEMBL185121 | 0.78 | BCL2 (0.85) | BCL2ACLYTP53SLC2A1TAS2R14 | |
| SCHEMBL184600 | 0.77 | BCL2 (1.00) | BCL2ACLYTP53TAS2R14MMP1 | |
| SCHEMBL184839 | 0.77 | BCL2 (0.84) | BCL2ACLYTP53TAS2R14MMP1 | |
| SCHEMBL184143 | 0.76 | BCL2 (0.81) | BCL2ACLYTP53TAS2R14MMP1 | |
| SCHEMBL15157614 | 0.75 | BCL2 (0.80) | BCL2ACLYSLC2A1TAS2R14MMP1 | |
| SCHEMBL184793 | 0.75 | BCL2 (0.80) | BCL2ACLYTP53TAS2R14MMP1 | |
| SCHEMBL184754 | 0.74 | BCL2 (0.79) | BCL2ACLYTAS2R14MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297103-B1 | HYDROXYPHENYLSULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-01-04 | — | — | EP | disclosed |