Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | SERPINA3 | P01011 | 1/20 | 0.49 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.39 |
| ▸ | CDK2 | P24941 | 5/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gs-9191 SCHEMBL2734675 | 1.00 | POLB (0.57) | POLBSERPINA3ADCY2CCNE1CDK2 | |
| SCHEMBL13818569 | 0.97 | POLB (0.54) | POLBSERPINA3ADCY2CCNE1CDK2 | |
| SCHEMBL2734676 | 0.95 | POLB (0.52) | POLBSERPINA3ADCY2CCNE1CDK2 | |
| SCHEMBL2734834 | 0.93 | POLB (0.58) | POLBSERPINA3ADCY2CCNE1CDK2 | |
| SCHEMBL2734833 | 0.91 | POLB (0.56) | POLBSERPINA3ADCY2CCNE1CDK2 | |
| SCHEMBL13210520 | 0.91 | POLB (0.52) | POLBSERPINA3ADCY2CCNE1CDK2 | |
| SCHEMBL12339243 | 0.91 | POLB (0.61) | POLBSERPINA3ADCY2CCNE1CDK2 | |
| SCHEMBL2759923 | 0.91 | POLB (0.62) | POLBSERPINA3ADCY2CCNE1CDK2 | |
| SCHEMBL2734884 | 0.89 | POLB (0.57) | POLBSERPINA3ADCY2CCNE1CDK2 | |
| SCHEMBL13210484 | 0.88 | POLB (0.52) | POLBSERPINA3ADCY2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088754-B2 | Anti-proliferative compounds, compositions, and methods of use thereof | GILEAD SCIENCES, INC. (US) | 2012-01-03 | — | — | US | disclosed |