SCHEMBL27351609

SCHEMBL27351609

O=C1CC[C@@H](N2Cc3ccc(COC(=O)Nc4cc(OC(F)(F)F)ccc4F)cc3C2=O)C(=O)N1

nearest known ligand 0.51

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 20/20 0.51
▸ CSNK1A1 P48729 2/20 0.51
▸ IKZF2 Q9UKS7 1/20 0.51
▸ GSPT1 P15170 7/20 0.47
▸ CYP2C19 P33261 1/20 0.46
▸ KCNH2 Q12809 1/20 0.46
▸ DDB1 Q16531 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30767695 1.00 CRBN (0.51) CRBNCSNK1A1IKZF2GSPT1CYP2C19
SCHEMBL27351610 1.00 CRBN (0.51) CRBNCSNK1A1IKZF2GSPT1CYP2C19
SCHEMBL26740495 1.00 CRBN (0.51) CRBNCSNK1A1IKZF2GSPT1CYP2C19
SCHEMBL31438897 1.00 CRBN (0.51) CRBNCSNK1A1IKZF2GSPT1CYP2C19
SCHEMBL26740499 0.94 CRBN (0.49) CRBNCSNK1A1IKZF2GSPT1CYP2C19
SCHEMBL26740658 0.93 CRBN (0.49) CRBNCSNK1A1IKZF2GSPT1CYP2C19
SCHEMBL26740461 0.92 CRBN (0.53) CRBNCSNK1A1IKZF2GSPT1CYP2C19
SCHEMBL26740467 0.92 CRBN (0.53) CRBNCSNK1A1IKZF2GSPT1CYP2C19
SCHEMBL29739376 0.90 CRBN (0.49) CRBNCSNK1A1IKZF2GSPT1CYP2C19
SCHEMBL29739487 0.90 CRBN (0.49) CRBNCSNK1A1IKZF2GSPT1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024015565-A1 METHODS OF PREPARING AN ISOINDOLINONE DERIVATIVE AND CRYSTAL FORMS THEREOF MONTE ROSA THERAPEUTICS, INC. (US) 2024-01-18 — — WO disclosed
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