Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.67 |
| ▸ | RPA1 | P27694 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.49 |
| ▸ | BCL2 | P10415 | 5/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27351926 | 0.90 | KMT2A (0.66) | SMN1; SMN2PPP1CARPA1MEN1KMT2A | |
| SCHEMBL9207383 | 0.90 | SMN1; SMN2 (0.53) | SMN1; SMN2PPP1CARPA1SMPD1MALT1 | |
| SCHEMBL9206875 | 0.87 | RPA1 (0.52) | SMN1; SMN2PPP1CARPA1MEN1KMT2A | |
| SCHEMBL14728132 | 0.86 | SMN1; SMN2 (0.86) | SMN1; SMN2PPP1CARPA1MEN1KMT2A | |
| SCHEMBL9208953 | 0.86 | CA9 (0.65) | SMN1; SMN2PPP1CARPA1SMPD1MALT1 | |
| SCHEMBL1514335 | 0.81 | RPA1 (0.80) | SMN1; SMN2PPP1CARPA1MEN1KMT2A | |
| SCHEMBL27331393 | 0.80 | SMN1; SMN2 (0.76) | SMN1; SMN2PPP1CARPA1MEN1KMT2A | |
| SCHEMBL878349 | 0.80 | SMN1; SMN2 (0.76) | SMN1; SMN2PPP1CARPA1MEN1KMT2A | |
| SCHEMBL9207808 | 0.80 | KMT2A (0.78) | SMN1; SMN2PPP1CARPA1MEN1KMT2A | |
| SCHEMBL27431457 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2PPP1CARPA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046506-C | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-11-17 | — | — | CN | disclosed |