Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.58 |
| ▸ | FLT1 | P17948 | 5/20 | 0.55 |
| ▸ | FLT4 | P35916 | 5/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.47 |
| ▸ | KIT | P10721 | 3/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL278849 | 1.00 | KDR (0.58) | KDRFLT1FLT4PDGFRBKIT | |
| SCHEMBL273272 | 1.00 | KDR (0.58) | KDRFLT1FLT4PDGFRBKIT | |
| SCHEMBL274221 | 0.94 | KDR (0.56) | KDRFLT1FLT4PDGFRBKIT | |
| SCHEMBL279328 | 0.94 | KDR (0.56) | KDRFLT1FLT4PDGFRBKIT | |
| SCHEMBL273571 | 0.91 | KDR (0.54) | KDRFLT1FLT4PDGFRBKIT | |
| SCHEMBL273333 | 0.91 | KDR (0.54) | KDRFLT1FLT4PDGFRBKIT | |
| SCHEMBL274497 | 0.90 | KDR (0.57) | KDRFLT1FLT4PDGFRBKIT | |
| SCHEMBL278848 | 0.88 | KDR (0.54) | KDRFLT1FLT4PDGFRBKIT | |
| SCHEMBL274622 | 0.86 | KDR (0.63) | KDRFLT1FLT4PDGFRBKIT | |
| SCHEMBL279027 | 0.81 | KDR (0.53) | KDRFLT1FLT4PDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2371822-A1 | Heterobicyclic carboxamides as inhibitors for kinases | Novartis AG (CH) | 2011-10-05 | — | — | EP | claimed |
| US-8133886-B2 | Heterobicyclic carboxamides as inhibitors for kinases | NOVARTIS AG (CH) | 2012-03-13 | — | — | US | disclosed |
| EP-2371822-A1 | Heterobicyclic carboxamides as inhibitors for kinases | Novartis AG (CH) | 2011-10-05 | — | — | EP | disclosed |