Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 7/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8377502 | 0.87 | KCNQ2 (0.74) | KCNQ2CYP3A4ALOX15TSHRADRA1D | |
| Hydrochloric Acid SCHEMBL28745488 | 0.86 | KCNQ2 (0.72) | KCNQ2CYP3A4ALOX15TSHRADRA1D | |
| SCHEMBL8379298 | 0.82 | KCNQ2 (0.57) | KCNQ2CYP3A4ALOX15TSHRADRA1D | |
| SCHEMBL27560557 | 0.80 | KCNQ2 (0.55) | KCNQ2CYP3A4ALOX15TSHRADRA1D | |
| SCHEMBL8377794 | 0.80 | KCNQ2 (0.64) | KCNQ2CYP3A4ALOX15TSHRADRA1D | |
| SCHEMBL7358470 | 0.80 | KCNQ2 (0.90) | KCNQ2CYP3A4ALOX15TSHRADRA1D | |
| Acetic Acid SCHEMBL27560555 | 0.80 | KCNQ2 (0.67) | KCNQ2CYP3A4ALOX15TSHRADRA1D | |
| SCHEMBL8378797 | 0.76 | KCNQ2 (0.62) | KCNQ2CYP3A4ALOX15TSHRADRA1D | |
| SCHEMBL8378999 | 0.75 | KCNQ2 (0.60) | KCNQ2CYP3A4ALOX15TSHRADRA1D | |
| SCHEMBL8377927 | 0.75 | KCNQ2 (0.67) | KCNQ2CYP3A4ALOX15TSHRADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1058495-C | Polycyclic systems and derivatives thereof as neurotransmitter release enhancers in the treatment of cognitive disorders, pharmaceutical compositions containing them and uses thereof | DU PONT MERCK PHARMA (US) | 2000-11-15 | — | — | CN | claimed |
| CN-1122135-A | Novel polycyclic systems and derivatives thereof as neurotransmitter release enhancers in the treatment of cognitive disorders | DU PONT MERCK PHARMA (US) | 1996-05-08 | — | — | CN | claimed |
| CN-1058495-C | Polycyclic systems and derivatives thereof as neurotransmitter release enhancers in the treatment of cognitive disorders, pharmaceutical compositions containing them and uses thereof | DU PONT MERCK PHARMA (US) | 2000-11-15 | — | — | CN | disclosed |
| CN-1122135-A | Novel polycyclic systems and derivatives thereof as neurotransmitter release enhancers in the treatment of cognitive disorders | DU PONT MERCK PHARMA (US) | 1996-05-08 | — | — | CN | disclosed |