Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.63 |
| ▸ | CDK4 | P11802 | 8/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.63 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.63 |
| ▸ | CDK1 | P06493 | 1/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.63 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.63 |
| ▸ | CCND1 | P24385 | 1/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.63 |
| ▸ | CCND3 | P30281 | 1/20 | 0.63 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.63 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.63 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.63 |
| ▸ | GSK3A | P49840 | 1/20 | 0.63 |
| ▸ | GSK3B | P49841 | 1/20 | 0.63 |
| ▸ | CDK7 | P50613 | 1/20 | 0.63 |
| ▸ | CDK9 | P50750 | 1/20 | 0.63 |
| ▸ | CCNH | P51946 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25122567 | 0.90 | CDK2 (0.74) | CDK2CDK4KCNH2CCNT1CDK1 | |
| SCHEMBL29991020 | 0.89 | CDK2 (0.64) | CDK2CDK4KCNH2CCNT1CDK1 | |
| SCHEMBL25122549 | 0.89 | CDK2 (0.64) | CDK2CDK4KCNH2CCNT1CDK1 | |
| SCHEMBL25123904 | 0.89 | CDK2 (0.64) | CDK2CDK4KCNH2CCNT1CDK1 | |
| SCHEMBL27229132 | 0.89 | CDK2 (0.66) | CDK2CDK4KCNH2CCNT1CDK1 | |
| SCHEMBL5098875 | 0.86 | CDK2 (0.81) | CDK2CDK4KCNH2CCNT1CDK1 | |
| SCHEMBL27370489 | 0.84 | CDK2 (0.69) | CDK2CDK4KCNH2CCNT1CDK1 | |
| SCHEMBL27360480 | 0.81 | KCNH2 (0.43) | CDK2CDK4KCNH2CCNT1CDK1 | |
| SCHEMBL4513992 | 0.78 | CDK2 (0.76) | CDK2CDK4KCNH2CCNT1CDK1 | |
| SCHEMBL27357551 | 0.78 | CDK2 (0.53) | CDK2CDK4KCNH2CCNT1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024039903-A2 | CDK2 INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2024-02-22 | — | — | WO | disclosed |