Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.42 |
| ▸ | NAMPT | P43490 | 4/20 | 0.42 |
| ▸ | PTAFR | P25105 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27361273 | 0.93 | HDAC6 (0.51) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL27361338 | 0.89 | HDAC6 (0.61) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL27361511 | 0.87 | HDAC6 (0.71) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL27361274 | 0.86 | HDAC2 (0.45) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL27362059 | 0.83 | NAMPT (0.39) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL27362078 | 0.82 | HDAC6 (0.59) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL27362057 | 0.81 | HDAC6 (0.45) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL27361448 | 0.81 | HDAC6 (0.71) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL30754590 | 0.81 | HDAC6 (0.50) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL27360991 | 0.81 | HDAC6 (0.50) | HDAC6HDAC8HDAC3HDAC2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024028654-A2 | HISTONE DEACETYLASE INHIBITORS AND USE OF THE SAME | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2024-02-08 | — | — | WO | disclosed |