Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 14/20 | 0.46 |
| ▸ | KDR | P35968 | 13/20 | 0.46 |
| ▸ | CDK2 | P24941 | 13/20 | 0.46 |
| ▸ | CDK7 | P50613 | 3/20 | 0.40 |
| ▸ | CDK9 | P50750 | 3/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29991317 | 1.00 | CDK1 (0.46) | CDK1KDRCDK2CDK7CDK9 | |
| SCHEMBL27225058 | 0.82 | IGF1R (0.34) | CDK1KDRCDK2CDK7CDK9 | |
| SCHEMBL10998952 | 0.80 | KDM4E (0.35) | CDK1KDRCDK2IGF1RCA2 | |
| SCHEMBL28300418 | 0.80 | KDM4E (0.42) | CDK1CDK2IGF1RLRRK2CCNB1 | |
| SCHEMBL29533105 | 0.80 | KDM4E (0.35) | CDK1KDRCDK2IGF1RCA2 | |
| SCHEMBL22200723 | 0.79 | APP (0.35) | CDK2MAPK8MAPK9GSK3BKDM4E | |
| SCHEMBL6416479 | 0.79 | KDM4E (0.35) | CDK1CDK2IGF1RCCNB1CCNE1 | |
| SCHEMBL25211340 | 0.78 | NTRK1 (0.35) | LMNAHTTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL5067063 | 0.77 | MEN1 (0.34) | CDK1KDRCDK2CA2LMNA | |
| SCHEMBL15357782 | 0.77 | KDR (0.47) | CDK1KDRCDK2CDK7CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024039903-A2 | CDK2 INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2024-02-22 | — | — | WO | disclosed |