Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 12/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22483010 | 0.83 | HDAC6 (0.72) | HDAC6HDAC11HDAC8HDAC3HDAC1 | |
| SCHEMBL27361975 | 0.81 | HDAC6 (0.68) | HDAC6HDAC11HDAC8HDAC3TAS2R14 | |
| SCHEMBL27361906 | 0.80 | HDAC6 (0.49) | HDAC6HDAC11HDAC8HDAC3HDAC1 | |
| SCHEMBL27362078 | 0.76 | HDAC6 (0.59) | HDAC6HDAC11HDAC8HDAC3TAS2R14 | |
| SCHEMBL27361448 | 0.73 | HDAC6 (0.71) | HDAC6HDAC11HDAC8HDAC3TAS2R14 | |
| SCHEMBL27362150 | 0.72 | HDAC6 (0.53) | HDAC6HDAC11HDAC8HDAC3HDAC1 | |
| SCHEMBL22482764 | 0.72 | HDAC6 (0.79) | HDAC6HDAC11HDAC8HDAC3HDAC1 | |
| SCHEMBL27362094 | 0.70 | HDAC6 (0.61) | HDAC6HDAC11HDAC8HDAC3HDAC1 | |
| SCHEMBL27361273 | 0.70 | HDAC6 (0.51) | HDAC6HDAC11HDAC8HDAC3TAS2R14 | |
| SCHEMBL27361718 | 0.70 | HDAC6 (0.63) | HDAC6HDAC11HDAC8HDAC3TAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024028654-A2 | HISTONE DEACETYLASE INHIBITORS AND USE OF THE SAME | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2024-02-08 | — | — | WO | disclosed |