Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 11/20 | 0.39 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.37 |
| ▸ | LATS1 | O95835 | 1/20 | 0.37 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369987 | 0.77 | MAPK1 (0.75) | MAPK1MAPK8MAPK9 | |
| SCHEMBL25625879 | 0.74 | MAPK1 (0.51) | MAPK1PCSK9CCNKCDK12 | |
| SCHEMBL10293575 | 0.73 | MAPK1 (0.70) | MAPK1 | |
| SCHEMBL30406752 | 0.72 | LRRK2 (0.39) | MAPK1MAPK8LATS1LATS2MAPK9 | |
| SCHEMBL24220845 | 0.72 | MAPK1 (0.68) | MAPK1 | |
| SCHEMBL17973022 | 0.72 | MAPK1 (0.68) | MAPK1CCNKCDK12 | |
| SCHEMBL24220836 | 0.70 | MAPK1 (0.66) | MAPK1MAPK8MAPK9CCNKCDK12 | |
| SCHEMBL31736992 | 0.69 | MAPK1 (0.64) | MAPK1MAPK8 | |
| SCHEMBL19144932 | 0.69 | MAPK1 (1.00) | MAPK1MAPK8MAPK9 | |
| SCHEMBL28386712 | 0.69 | MAPK8 (0.50) | MAPK1MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |