SCHEMBL27364075

SCHEMBL27364075

Oc1cc(O)cc(-c2cc3ccc(O)cc3s2)c1

nearest known ligand 0.76

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 10/20 0.76
ESR2 Q92731 10/20 0.76
APP P05067 1/20 0.53
HSD17B1 P14061 4/20 0.51
HSD17B2 P37059 3/20 0.51
ABL1 P00519 2/20 0.47
ABCB1 P08183 2/20 0.47
BCR P11274 2/20 0.47
CA2 P00918 1/20 0.46
TYR P14679 1/20 0.41
PTGS1 P23219 1/20 0.41
PTGS2 P35354 1/20 0.41
PDE4B Q07343 1/20 0.41
PDE4D Q08499 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Raloxifene Core SCHEMBL2567321 0.86 ESR1 (1.00) ESR1ESR2APPHSD17B1HSD17B2
Raloxifene Core SCHEMBL29941293 0.86 ESR1 (1.00) ESR1ESR2APPHSD17B1HSD17B2
SCHEMBL7643423 0.83 ESR1 (1.00) ESR1ESR2APPHSD17B1HSD17B2
SCHEMBL13071222 0.80 ESR1 (0.80) ESR1ESR2APPHSD17B1HSD17B2
SCHEMBL19171602 0.80 ESR1 (0.80) ESR1ESR2APPHSD17B1HSD17B2
SCHEMBL204092 0.80 ESR1 (0.80) ESR1ESR2APPHSD17B1HSD17B2
SCHEMBL3139631 0.80 ESR1 (1.00) ESR1ESR2APPHSD17B1HSD17B2
SCHEMBL3144561 0.76 ESR1 (0.73) ESR1ESR2APPHSD17B1HSD17B2
SCHEMBL3148543 0.76 ESR1 (0.73) ESR1ESR2APPHSD17B1HSD17B2
SCHEMBL21735520 0.76 ESR1 (0.69) ESR1ESR2APPHSD17B1HSD17B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024054685-A2 BOTANICAL COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF ARKANSAS STATE UNIVERSTIY-JONESBORO (US) 2024-03-14 WO disclosed