SCHEMBL27366632

SCHEMBL27366632

CN1CCN(Cc2ccc(-c3c(-c4cnn(C)c4)oc4ncnc(Oc5ccc(NC(=O)c6cccn(-c7ccc(F)cc7)c6=O)cc5)c34)cc2)CC1

nearest known ligand 0.86

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 20/20 0.86
AXL P30530 19/20 0.86
TYRO3 Q06418 4/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27367246 0.90 MERTK (0.69) MERTKAXLTYRO3
SCHEMBL27366547 0.90 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27365775 0.90 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27365857 0.89 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27365943 0.88 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27365861 0.88 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27365859 0.86 MERTK (0.88) MERTKAXLTYRO3
SCHEMBL32685181 0.86 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27365942 0.86 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27365850 0.86 MERTK (1.00) MERTKAXLTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed